Endocrine Abstracts

Background: Obesity is associated with increased atherogenesis through alterations in lipids, among other potential factors. Some of those abnormalities might be mediated by insulin resistance (IR).Aims: To compare lipid and apolipoprotein profile between lean and obese women; to evaluate the influence of IR on lipid and apolipoprotein profile, in obese women.Methods: We studied 112 obese and 100 normal-weight premenopausal women w...

Introduction: Arthropathy affects the majority of acromegalic patients and is a major cause of morbidity, absenteeism and impaired quality of life. GH excess and increased levels of circulating IGFI result initially in a marked thickening of the soft tissues and cartilage. Along with disease progression, there’s subperiostal bone neoapposition, cartilage regressive phenomena and bone structural changes. We aimed to investigate prevalence, clinical presentation, treatment ...

Introduction: Post-surgical hypoparathyroidism is a well known complication of total thyroidectomy. It may occur as transitory hypoparathyroidism that spontaneously recover within a few weeks/months and as permanent hypoparathyroidism needing long-term treatment. Only few cases of hypoparathyroidism newly diagnosed many years after surgery have been reported. We present a patient with hypoparathyroidism that became clinically evident 15 years after the thyroid surgery.<p c...

Recent data have shown that, in parallel to its transcriptional action down-regulating TSH synthesis, triiodothyronine (T3) also acts on posttranscriptional steps of beta TSH synthesis, reducing the polyadenylation and translational rate of the beta TSH mRNA, when acutely administered to thyroidectomized rats. This study aimed to investigate whether these effects also occur in TalphaT1 cells, and if they are dependent on gene transcription, which would characterize ...

Thyroid nodules are common and majority is benign. Even so, clinicians and patient always concern about the risk for malignancy. In the past it was believed that hyperthyroidism excluded the possibility of a thyroid carcinoma. We describe here two patients presenting “hot” thyroid nodules with final diagnosis of papillary thyroid carcinoma. Informed consent was obtained. Case 1: A 39-years-old female, presenting with irritability, disquiet, and neck swelling. A nodul...

Introduction: Thyroid incidentaloma in 18F-FDG PET-CT is relatively common and the most focal uptake are benign. However, the risk of malignancy of thyroid lesions with focal uptake on 18F-FDG PET-CT is 34.8%. Metastasis to the thyroid is uncommon (less than 0.2% of thyroid fine needle aspiration – FNA - puncture findings), with renal neoplasms being the most frequently associated (48.1%) and, more rarely, those from the breast (7.8%).Case report: A...

Introduction: Adrenal oncocytoma (AO) and ganglioneuroma (GN) are rare causes of adrenal masses, corresponding usually to nonfunctional and benign tumors. However, 20% of the AO shows some elements of malignancy and 10–20% of them affect adrenal hormone production. GNs account for 0.3%-2% of adrenal incidentalomas, with punctate calcifications in CT imaging being highly suggestive. However, preoperative differential diagnosis remains challenging. Adrenal arterial emboliza...

While nonskeletal benefits of vitamin D remain a matter o debate, its importance in bone health is known for decades. Secondary hyperparathyroidism is considered to play a significant role in the pathogenesis of age-related bone loss. In the present study we investigate the association between serum PTH, 25-hydroxyvitamin (25(OH)D) and other clinically related variables in a cross sectional sample of patients followed in an Endocrine consultation during the year 2016. Patients...

The hypo and hyperthyroidism alter the synthesis/secretion of pituitary hormones, which in normal conditions present fluctuations in serum concentration during the 24h period. An intrinsic pituitary circadian clock might be related to these oscillations; however, the possible interaction between thyroid hormonal conditions and circadian clock gene expression in anterior pituitary is still unknown. The purpose of this study was to investigate the expression of core circadian cl...

Introduction: LDL cholesterol (LDL-C) is a major risk factor for atherosclerosis. The Friedewald formula (FF) is limited by hypertriglyceridaemia. We aimed to correlate serum LDL-C measured by direct assay with serum LDL-C estimated by several formulas: Friedewald (FF): LDL-C=CT-HDL−TG/5; Tsai (TsaiF): LDL-C=TC-HDL−TG/8 (TG/8 represents very-LDL-C); DeLong (DeLongF): LDL-C=TC-HDL−TG×0.16 and Chen (ChenF): LDL-C=non-HDL-cholesterol×0.9−TG×...